Multicenter Study of Azole-Resistant Aspergillus fumigatus Clinical Isolates, Taiwan 1

Chi-Jung Wu, Wei-Lun Liu, Chih-Cheng Lai, Chien-Ming Chao, Wen-Chien Ko, Hsuan-Chen Wang, Ching-Tzu Dai, Ming-I Hsieh, Pui-Ching Choi, Jia-Ling Yang, Yee-Chun Chen
Emerging Infectious Diseases 2020, 26 (4): 804-806
In a multicenter study, we determined a prevalence rate of 4% for azole-resistant Aspergillus fumigatus in Taiwan. Resistance emerged mainly from the environment (TR34 /L98H, TR34 /L98H/S297T/F495I, and TR46 /Y121F/T289A mutations) but occasionally during azole treatment. A high mortality rate observed for azole-resistant aspergillosis necessitates diagnostic stewardship in healthcare and antifungal stewardship in the environment.

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