The effect of vitamin d status on different neuromuscular blocker agents reverse time.

BACKGROUND: This study is aimed to investigate the effects of vitamin D levels on sugammadex and neostigmine reversal times.

METHODS: Eighty patients between the ages of 18 and 65 years, with ASA I-III status who were undergoing surgery under general anaesthesia were included in the study. A double blind fashion was used to randomly divide all the patients into two groups. At the end of the operation, sugammadex 2 mg / kg was administered to one group (Group sugammadex) and atropine and neostigmine was administered to the other group Group neostigmine) intravenously. In the data analysis stage, the group was divided into two subgroups according to sugammadex and group neostigmine in itself, with vitamin D levels above and below 30 ng / ml. Statistical analysis was performed on these 4 groups. (Group neostigmine and vitamin D < 30 ng / ml), (Group neostigmine and vitamin D ? 30 ng / ml), ( Group sugammadex and vitamin D < 30 ng / ml), (Group sugammadex and vitamin D ? 30 ng / ml). When two responses to train of four (TOF) stimulation were taken, the following times were recorded until extubation phase. The time until TOF value 50%, 70%, 90% and extubation were recorded.

RESULTS: There were statistically difference between Group sugammadex and vitamin D < 30 ng / ml and Group sugammadex and vitamin D ? 30 ng / ml (p=0.007) for extubation times and 50% TOF reach times (p=0,015). But there was no differences observed between Group neostigmine and vitamin D < 30 ng / ml and Group neostigmine and vitamin D ? 30 ng / ml. (p=0.999) Conclusion: Vitamin D deficiency is important for anaesthesiologists in terms of muscle strength and extubation time. Vitamin D deficiency seems may effect on sugammadex reverse times but not effect on neostigmine reverse times. This conclusion needs further studies.