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Lack of Benefit of High-Dose Vitamin C, Thiamine, and Hydrocortisone Combination for Patients With Sepsis

Andre C Kalil

JAMA 2020 February 4, 323 (5): 419-420

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Posted 19 Jan, 2020 at 18:39

The Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) Protocol: a prospective, multi-center, double-blind, adaptive sample size, randomized, placebo-controlled, clinical trial. David N Hager, Michael H Hooper, Gordon R Bernard, Laurence W Busse, E Wesley Ely, Alpha A Fowler, David F Gaieski, Alex Hall, Jeremiah S Hinson, James C Jackson, Gabor D Kelen, Mark Levine, Christopher J Lindsell, Richard E Malone, Anna McGlothlin, Richard E Rothman, Kert Viele, David W Wright, Jonathan E Sevransky, Greg S Martin Trials 2019 April 5, 20 (1): 197

Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study. Paul E Marik, Vikramjit Khangoora, Racquel Rivera, Michael H Hooper, John Catravas Chest 2017, 151 (6): 1229-1238

Hydrocortisone, Vitamin C and thiamine for the treatment of sepsis and septic shock following cardiac surgery. Mahesh Balakrishnan, Hemang Gandhi, Komal Shah, Himani Pandya, Ramesh Patel, Sunny Keshwani, Nikhil Yadav Indian Journal of Anaesthesia 2018, 62 (12): 934-939

Effect of Vitamin C, Hydrocortisone, and Thiamine vs Hydrocortisone Alone on Time Alive and Free of Vasopressor Support Among Patients With Septic Shock: The VITAMINS Randomized Clinical Trial. Tomoko Fujii, Nora Luethi, Paul J Young, Daniel R Frei, Glenn M Eastwood, Craig J French, Adam M Deane, Yahya Shehabi, Ludhmila A Hajjar, Gisele Oliveira, Andrew A Udy, Neil Orford, Samantha J Edney, Anna L Hunt, Harriet L Judd, Laurent Bitker, Luca Cioccari, Thummaporn Naorungroj, Fumitaka Yanase, Samantha Bates, Forbes McGain, Elizabeth P Hudson, Wisam Al-Bassam, Dhiraj Bhatia Dwivedi, Chloe Peppin, Phoebe McCracken, Judit Orosz, Michael Bailey, Rinaldo Bellomo JAMA: the Journal of the American Medical Association 2020 January 17

Hydrocortisone, Vitamin C and Thiamine for Sepsis: Whither the Ethics in Research? Ian C Michelow, Zaid Alhinai, Penelope H Dennehy Chest 2017, 152 (3): 689-690

Vitamin C, Thiamine, and Steroids in the Sepsis Conquest: Replete to Defeat. Erenie Guirguis, Yasmin Grace, Harm Maarsingh, Thi Ca Tran, Elena Tkachuk Journal of Pharmacy Practice 2020, 33 (5): 682-695

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