Response to "Reply to: 'The decreasing predictive power of MELD in an era of changing etiology of liver disease'"

Elizabeth L Godfrey, Tahir H Malik, Jennifer C Lai, Ayse L Mindikoglu, N Thao N Galván, Ronald T Cotton, Christine A O'Mahony, John A Goss, Abbas Rana
American Journal of Transplantation 2020 January 14
We appreciate Kwong et al.'s utilization of Harrell's c-statistic and its ability to incorporate follow-up time as a valuable contribution to the discussion about our group's findings.1 We acknowledge that the conventional area under receiver-operating-characteristic curve concordance statistic has limitations; however, we selected the conventional c-statistic to remain methodologically consistent with the manner in which the Model for End-Stage Liver Disease (MELD) was originally designed and validated, first to predict post-TIPS survival, then when applied to ESLD generally, and finally when integrated into allocation.

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