No association between alpha-tocopherol levels with pulmonary function or exacerbations in cystic fibrosis.

Most patients with cystic fibrosis (CF) need daily fat-soluble vitamins, but are not always able to achieve the optimal serum levels. The activity of vitamin E is the cumulative function of eight naturally occurring tocopherols. The most potent is alpha-tocopherol and vitamin E deficiency is diagnosed when the serum concentration of this tocopherol is less than 500 µg/dL. Due to its antioxidant properties, Vitamin E may play a protective role in the lungs and it has been associated with less pulmonary exacerbations and better lung function (1,2).