Posttransplant Lymphoproliferative Disorders Presenting as an External Nasal Deformity: A Case Report

Jingjing Yuan, Zhanfeng Yan, Jinfeng Liu, Ningyu Wang
Ear, Nose, & Throat Journal 2020 January 7, : 145561319898940

INTRODUCTION: Posttransplant lymphoproliferative disorder (PTLD) is a serious disease that usually occurs after solid organ transplant and stem cell transplant. Posttransplant lymphoproliferative disorder often involves the head and neck, but it is rare to present as a nasal deformity. Here, we describe a case of external nasal enlargement resulting from PTLD.

CASE REPORT: A 40-year-old man presented with an enlarged external nose half a year ago. The nasal ala thickened, and the external nose was gradually enlarged, accompanied by bilateral nasal obstructions. A biopsy was taken under endoscopy procedure, and the result suggested a diagnosis of PTLD.

DISCUSSION: Posttransplant lymphoproliferative disorder usually appears in lymphoid tissues that form Waldeyer's rings or cervical lymph nodes in the head and neck. The early involvement of other head and neck subpoints is considered rare. This case is the first report of PTLD presenting as an external nasal deformity. The symptoms and clinical manifestations of PTLD in otorhinolaryngology are usually diverse and nonspecific but are early symptoms in the clinical course of PTLD.

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