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Single nucleotide polymorphisms in dopamine receptor D2 are associated with bruxism and its circadian phenotypes in children.

Objective : To evaluate the association of bruxism phenotypes with single nucleotide polymorphisms in FKBP5, DRD2, ANKK1 , and COMT . Methods : Clinical oral examination was performed to diagnose bruxism phenotypes in 150 children. DNA was collected from saliva. Logistic univariate regression, Chi-square, and Fisher's exact tests were performed ( p < 0.05). Results : Bruxism was associated with DRD2 ( p = 0.02). Tooth grinding while awake was associated with ANKK1 ( p < 0.001), and tooth grinding while asleep was associated with DRD2 in the additive ( p = 0.030) and dominant ( p = 0.008) model. Tooth clenching while awake was associated with ANKK1 in the additive ( p = 0.005) and dominant ( p = 0.008) models, whereas tooth clenching while asleep was associated with ANKK1 ( p < 0.001) and with COMT in the additive ( p = 0.001) and dominant ( p = 0.003) models. Discussion : Polymorphisms in DRD2, ANKK1 , and COMT are associated with bruxism phenotypes.

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