Response of Lichen Planopilaris to Pioglitazone Hydrochloride

Erik L. Peterson, Daniel Gutierrez, Nooshin K. Brinster, Kristen I. Lo Sicco, Jerry Shapiro
Journal of Drugs in Dermatology: JDD 2019 December 1, 18 (12): 1276-1279
Lichen planopilaris (LPP) is a cicatricial alopecia that often causes permanent hair loss. Pioglitazone, a peroxisome proliferator activated receptor-gamma (PPAR- γ) agonist, has demonstrated immunomodulatory properties that may offer an effective treatment modality. This retrospective analysis describes 23 patients with LPP treated with adjunctive pioglitazone. Most (18/25) demonstrated significant reduction in patient-reported symptoms and clinical signs of inflammation. No adverse effects were reported. J Drugs Dermatol. 2019;18(12):1276-1279.

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