JOURNAL ARTICLE
REVIEW

XPC beyond nucleotide excision repair and skin cancers

Abir Zebian, Abdullah Shaito, Frédéric Mazurier, Hamid Reza Rezvani, Kazem Zibara
Mutation Research 2019, 782: 108286
31843141
Xeroderma pigmentosum group C (XPC) has been known as a DNA damage recognition factor of bulky adducts and as an initiator of global genome nucleotide excision repair (GG-NER). XP-C patients have been shown to have a predisposition to develop skin and certain internal cancers. Recent studies have shown that XPC presents several functional and molecular interactions with fundamental players in several other DNA repair pathways including base excision repair (BER). Furthermore, novel clues indicate that XPC is involved in transcription regulation in the cell. In this review, association between abnormal XPC activity as well as several XPC polymorphisms with the incidence of non-skin tumors is discussed. We also review the current literature regarding the roles of XPC in different DNA repair pathways, highlighting its tumor suppressor activity that may occur independently of its conventional function in NER. Deciphering the NER-independent involvement of XPC in onset and progress of non-skin cancers will have positive implications on prognosis and therapy of cancers with XPC deficiency.

Full Text Links

Find Full Text Links for this Article

Discussion

You are not logged in. Sign Up or Log In to join the discussion.

Related Papers

Remove bar
Read by QxMD icon Read
31843141
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"