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Kimura's disease: Effects of age on clinical presentation

Eiichi Kakehi, Kazuhiko Kotani, Yuma Otsuka, Yusuke Fukuyasu, Yasuhiro Hashimoto, Shigehisa Sakurai, Akane Hirotani, Kaduyo Simizu, Ryosuke Fujita, Keisuke Shoji, Seiji Adachi, Masami Matsumura
QJM: Monthly Journal of the Association of Physicians 2019 December 4

BACKGROUND: Kimura's disease (KD) is known to be dominant among young Asian men, but it can also occur in middle- and advanced-aged people. The clinical characteristics of KD, especially by age, are not well known.

AIM: This study was performed to investigate the effects of age on the clinical characteristics of KD.

DESIGN: We conducted a case series study.

METHODS: All case studies of patients diagnosed with KD were collected via a PubMed search of studies published until August 2018. The data were analyzed by age group.

RESULTS: In total, 215 studies were reviewed (238 patients; mean age of 36 years). The male: female ratio was 4:1 overall, 17:1 in patients aged <20 years, 4:1 in patients aged 20 to39 years, and 2:1 in patients aged ≥40 years (p = 0.01). The percentage of patients with pruritus was 15.4% overall, 3.8% in patients aged <20 years, 15.5% in patients aged 20 to 39 years, and 21.7% in patients aged ≥40 years (p = 0.02). The time to diagnosis was 5.3 years overall, 3.2 years in patients aged <20 years, 4.7 years in patients aged 20 to 39 years, and 7.1 years in patients aged ≥40 years (p < 0.01).

CONCLUSIONS: The proportion of female patients affected, the incidence of pruritus, and the time to diagnosis increased as the patients' age increased. There were no significant age-related differences in region/race, complications, multiplicity, laterality, anatomical distribution, maximum size, eosinophil count, IgE level, initial treatment, recurrence, or outcomes. This may be useful information for the diagnosis of KD.

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