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Journal Article
Research Support, U.S. Gov't, P.H.S.
Review
Advances in Genomic Profiling and Risk Stratification in Acute Myeloid Leukemia.
Seminars in Oncology Nursing 2019 December
OBJECTIVE: To review the current state of molecular and genetic profiling of acute myeloid leukemia (AML) and its implications.
DATA SOURCE: Peer-reviewed journal articles.
CONCLUSION: Significant advances in the understanding of the pathology of acute myeloid leukemia have led to refined risk stratification of patients and application of novel targeted therapies based on genetic profiles. Minimal residual disease testing allows for highly sensitive disease surveillance that can be used to predict relapse and assess treatment response.
IMPLICATIONS FOR NURSING PRACTICE: Accurate prognostication and therapeutic decision-making for patients with acute myeloid leukemia is dependent on molecular profiling. Being knowledgeable of the implications of minimal residual disease testing is critical for patient-centered care.
DATA SOURCE: Peer-reviewed journal articles.
CONCLUSION: Significant advances in the understanding of the pathology of acute myeloid leukemia have led to refined risk stratification of patients and application of novel targeted therapies based on genetic profiles. Minimal residual disease testing allows for highly sensitive disease surveillance that can be used to predict relapse and assess treatment response.
IMPLICATIONS FOR NURSING PRACTICE: Accurate prognostication and therapeutic decision-making for patients with acute myeloid leukemia is dependent on molecular profiling. Being knowledgeable of the implications of minimal residual disease testing is critical for patient-centered care.
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