Novel plasmid-mediated tet (X5) gene conferring resistance to tigecycline, eravacycline and omadacycline in clinical Acinetobacter baumannii

Liyuan Wang, Dejun Liu, Yuan Lv, Lanqing Cui, Yun Li, Tianmeng Li, Huangwei Song, Yuxin Hao, Jianzhong Shen, Yang Wang, Timothy R Walsh
Antimicrobial Agents and Chemotherapy 2019 October 14
A novel, plasmid-mediated, high-level tigecycline resistance tet (X) gene variant, tet (X5), was detected in a clinical Acinetobacter baumannii isolate from China in 2017. Tet(X5) shows 84.5% and 90.5% amino acid identity to Tet(X3) and Tet(X4), respectively, with similar binding sites and a comparable affinity for tetracyclines. The tet (X5)-containing plasmid could only be transferred to A. baumannii via electro-transformation. This report follows the recent study describing the identification of tet (X3) and tet (X4).

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