OPEN IN READ APP
JOURNAL ARTICLE

Towards Machine Learning Prediction of Deep Brain Stimulation (DBS) Intra-operative Efficacy Maps

Camilo Bermudez, William Rodriguez, Yuankai Huo, Allison E Hainline, Rui Li, Robert Shults, Pierre D D'Haese, Peter E Konrad, Benoit M Dawant, Bennett A Landman
Proceedings of SPIE 2019, 10949
31602087
Deep brain stimulation (DBS) has the potential to improve the quality of life of people with a variety of neurological diseases. A key challenge in DBS is in the placement of a stimulation electrode in the anatomical location that maximizes efficacy and minimizes side effects. Pre-operative localization of the optimal stimulation zone can reduce surgical times and morbidity. Current methods of producing efficacy probability maps follow an anatomical guidance on magnetic resonance imaging (MRI) to identify the areas with the highest efficacy in a population. In this work, we propose to revisit this problem as a classification problem, where each voxel in the MRI is a sample informed by the surrounding anatomy. We use a patch-based convolutional neural network to classify a stimulation coordinate as having a positive reduction in symptoms during surgery. We use a cohort of 187 patients with a total of 2,869 stimulation coordinates, upon which 3D patches were extracted and associated with an efficacy score. We compare our results with a registration-based method of surgical planning. We show an improvement in the classification of intraoperative stimulation coordinates as a positive response in reduction of symptoms with AUC of 0.670 compared to a baseline registration-based approach, which achieves an AUC of 0.627 (p < 0.01). Although additional validation is needed, the proposed classification framework and deep learning method appear well-suited for improving pre-surgical planning and personalize treatment strategies.

Discussion

You are not logged in. Sign Up or Log In to join the discussion.

Related Papers

Available on the App Store

Available on the Play Store
Remove bar
Read by QxMD icon Read
31602087
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"