Complete Nucleotide Sequence of a Novel Plasmid Bearing the High-Level Tigecycline Resistance Gene, tet (X4)

Liang-Xing Fang, Chong Chen, Dong-Ling Yu, Ruan-Yang Sun, Chao-Yue Cui, Liang Chen, Xiao-Ping Liao, Ya-Hong Liu, Jian Sun
Antimicrobial Agents and Chemotherapy 2019 September 3
We reported the complete nucleotide sequence of a tet (X4)-carrying plasmid, pSTB20-1T, from a tigecycline-resistant Escherichia coli isolate in China. Sequence analysis indicated that pSTB20-1T contains a hybrid plasmid backbone and a tet (X4)-containing multidrug resistance region, likely originated through recombination of multiple plasmids. tet(X4 ) was flanked by two IS CR2, which may be responsible for tet (X4) mobilization. The occurrence and transmission of this novel hybrid plasmid may exacerbate the spread of the clinically significant tet (X4) gene.

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