We have located links that may give you full text access.
Validity and reliability of extrastriatal [ 11 C]raclopride binding quantification in the living human brain.
NeuroImage 2019 August 30
[11 C]raclopride is a well established PET tracer for the quantification of dopamine 2/3 receptors (D2/3 R) in the striatum. Outside of the striatum the receptor density is up to two orders of magnitude lower. In contrast to striatal binding, the characteristics of extrastriatal [11 C]raclopride binding quantification has not been thoroughly described. Still, binding data for e.g., neocortex is frequently reported in the scientific literature. Here we evaluate the validity and reliability of extrastriatal [11 C]raclopride binding quantification. Two sets of healthy control subjects were examined with HRRT and [11 C]raclopride: (i) To assess the validity of extrastriatal [11 C]raclopride binding estimates, eleven subjects were examined at baseline and after dosing with quetiapine, a D2/3 R antagonist. (ii) To assess test-retest repeatability, nine subjects were examined twice. Non displaceable binding potential (BPND ) was quantified using the simplified reference tissue model with cerebellum as reference. Quetiapine dosing was associated with decrease in [11 C]raclopride BPND in temporal cortex (18 ± 17% occupancy) and thalamus (20 ± 17%), but not in frontal cortex. Extrastriatal occupancy was lower than in putamen (51 ± 4%). The mean absolute variation was 4-7% in the striatal regions, 17% in thalamus, and 13-59% in cortical regions. Our data indicate that [11 C]raclopride PET, quantified using cerebellum as reference, is not a suitable tool to measure D2/3 R in extrastriatal regions.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app