Vulnerable carotid plaque ánd biomarkers: multiplying individual risk profiles?

Wu et al wrote an interesting manuscript that elaborates about a burning clinical question. (1) The study design contains a large population to address their man question: if non-HDL-C level is associated with prevalence of asymptomatic vulnerable carotid atherosclerotic plaque. Particularly the latter, collecting such a large population with asymptomatic patients with a vulnerable plaque, deservers credits. The most important question I had reading this important paper is how exactly the vulnerability of the (asymptomatic) plaque was defined. This concern is underlined by the in my opinion very high prevalence of a vulnerable plaque in asymptomatic patients, Were these patients with strong CV risk factors otherwise?. This article is protected by copyright. All rights reserved.