JOURNAL ARTICLE

Emergence of mobile tigecycline resistance mechanism in Escherichia coli strains from migratory birds in China

Chong Chen, Chao-Yue Cui, Yan Zhang, Qian He, Xiao-Ting Wu, Gong Li, Xiao-Ping Liao, Barry N Kreiswirth, Ya-Hong Liu, Liang Chen, Jian Sun
Emerging Microbes & Infections 2019, 8 (1): 1219-1222
31429665
Plasmid-mediated antimicrobial resistance has emerged as one of the principal global issues, posing significant threats to public health. Herein, we reported a mobile tigecycline resistance mechanism Tet(X4) on both plasmid and chromosome in Escherichia coli strains from migratory birds in China. Besides tigecycline, these tet (X4)-positive strains also exhibited elevated MICs to the FDA newly approved tetracycline antibiotics, eravacycline (4 µg/ml) and omadacycline (8 µg/ml). Worrisomely, the tet (X4)-carrying plasmids and chromosome also shared high homology with the plasmids from human. Taken together, Tet(X4) represents another emerging antimicrobial threat and collective efforts from different sectors are needed to control its further spread.

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