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Invited Editorial re: Vendor-Specific Microbiome Controls both Acute and Chronic Murine Lung Allograft Rejection by Altering CD4+Foxp3+ Regulatory T Cell Levels.

Despite advances in immunosuppressive management in lung transplantation, acute and chronic rejection remain challenging. One under-studied area of research is the role of the microbiota and its effects on alloimmunity and allograft rejection. Prior work has shown that the microbiota modulates innate and adaptive immunity through pathways such as the induction of suppressive Foxp3+ CD4+ regulatory T cells (Treg). Guo et al in this issue of the AJT demonstrate vendor-specific differences in lung allograft rejection in a minor histocompatibility mismatch murine model, and these differences are ameliorated by antibiotics. The authors thus focused on the microbiota and investigated whether the association between microbiota and lung allograft rejection may be related to microbiota-induced alterations in Treg responses. This article is protected by copyright. All rights reserved.

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