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Synthesis of Recoded Bacterial Genomes toward Bespoke Biocatalysis.
Trends in Biotechnology 2019 July 14
Ongoing efforts in synthetic biology aim at constructing (micro)organisms with (pre)defined properties. A recent breakthrough is the chemical synthesis of a recoded Escherichia coli genome by Fredens et al. (Nature, 2019). Besides the conceptual and technological tour de force, the consequences of this unprecedented effort for whole-cell biocatalysis are multifold.
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