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Effects of Conventional Milk Versus Milk Containing Only A2 β-Casein on Digestion in Chinese Children: A Randomized Study

Sheng Xiaoyang, Li Zailing, Jiayi Ni, Greg Yelland
Journal of Pediatric Gastroenterology and Nutrition 2019 July 9

OBJECTIVES: In this study, we hypothesized that replacing conventional milk, which contains A1 and A2 β-casein (A1 milk), with milk that contains only A2 β-casein (A2 milk) in the diet of dairy or milk-intolerant preschoolers would result in reduced gastrointestinal symptoms associated with milk intolerance, and that this would correspond with cognitive improvements.

METHODS: This randomized, double-blind, crossover study aimed to compare the effects of 5 days' consumption of conventional milk versus A2 milk on gastrointestinal symptoms, as assessed via visual analog scales, average stool frequency and consistency, and serum inflammatory and immune biomarkers in healthy preschoolers with mild-to-moderate milk intolerance. The study also aimed to compare changes in the cognitive behavior of preschoolers, based on Subtle Cognitive Impairment Test scores.

RESULTS: Subjects who consumed A2 milk had significantly less severe gastrointestinal symptoms as measured by visual analog scales, reduced stool frequency, and improvements in stool consistency, compared with subjects consuming conventional milk. There were significant increases from baseline in serum interleukin-4, immunoglobulins G, E, and G1, and beta-casomorphin-7 coupled to lower glutathione levels, in subjects consuming conventional rather than A2 milk. Subtle Cognitive Impairment Test analysis showed significant improvements in test accuracy after consumption of A2 milk. There were no severe adverse events related to consumption of either milk product.

CONCLUSIONS: Replacing conventional milk with A2 milk reduced gastrointestinal symptoms associated with milk intolerance in Chinese preschool children, with corresponding improvements in aspects of cognitive performance.


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