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Survivors of Ebola virus disease develop polyfunctional antibody responses.
Journal of Infectious Diseases 2019 July 13
BACKGROUND: Monoclonal antibodies can mediate protection against Ebola virus (EBOV) infection through direct neutralization as well as through the recruitment of innate immune effector functions. However, the antibody functional response following survival of acute EBOV disease has not been well characterized.
METHODS: Serum antibodies from EVD survivors from Sierra Leone were profiled to capture variation in overall subclass/isotype abundance, neutralizing activity, and innate immune effector functions.
RESULTS: Antibodies from EVD survivors exhibit robust innate immune effector functions, mediated primarily by IgG1 and IgA1.
CONCLUSIONS: Development of functional antibodies follows survival of acute EVD.
METHODS: Serum antibodies from EVD survivors from Sierra Leone were profiled to capture variation in overall subclass/isotype abundance, neutralizing activity, and innate immune effector functions.
RESULTS: Antibodies from EVD survivors exhibit robust innate immune effector functions, mediated primarily by IgG1 and IgA1.
CONCLUSIONS: Development of functional antibodies follows survival of acute EVD.
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