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Capnography monitoring of non-anesthesiologist provided sedation during percutaneous endoscopic gastrostomy (PEG) placement. A prospective, controlled, randomized trial.
Journal of Gastroenterology and Hepatology 2019 June 21
BACKGROUND AND AIM: A number of studies were able to show a reduction of hypoxemia episodes during procedural sedation through the use of capnography (CA). The present study investigates the number of episodes of hypoxemia during percutaneous endoscopic gastrostomy (PEG) placement with propofol sedation comparing standard monitoring (SM) vs. SM with additional CA surveillance.
METHODS: In this single-center randomized controlled trial 150 patients were prospectively randomized 1:1 in either the SM or CA group after stratification for ASA class, PEG method (push- or pull method), presence of head & neck tumor and tracheostomy. CA analysis was performed for all patients but was blinded for the endoscopic team in the SM group.
RESULTS: In the SM group, 57% episodes of hypoxemia (SpO2 <90% for >15sec) and 41% episodes of severe hypoxemia (SpO2 <85% for >15sec) were observed in comparison to 28% and 20% in the CA group, respectively. Odds ratios for hypoxemia and severe hypoxemia were 0.29 (CI 0.15-0.57; p=0.0005) and 0.35 (CI 0.17-0.73; p=0.008) in favor of the CA-group. On average, CA was able to detect imminent mild and severe hypoxemia 83 and 99 seconds before standard monitoring. Standard monitoring represented an independent risk factor for hypoxemia and severe hypoxemia.
CONCLUSIONS: Respiratory complications of sedation during PEG placement are frequent events. CA is able to detect imminent hypoxemia at an early time point. This allows an early intervention and consecutively the avoidance of mild and severe hypoxemia. Therefore, CA monitoring can be recommended particularly during PEG insertion procedures.
METHODS: In this single-center randomized controlled trial 150 patients were prospectively randomized 1:1 in either the SM or CA group after stratification for ASA class, PEG method (push- or pull method), presence of head & neck tumor and tracheostomy. CA analysis was performed for all patients but was blinded for the endoscopic team in the SM group.
RESULTS: In the SM group, 57% episodes of hypoxemia (SpO2 <90% for >15sec) and 41% episodes of severe hypoxemia (SpO2 <85% for >15sec) were observed in comparison to 28% and 20% in the CA group, respectively. Odds ratios for hypoxemia and severe hypoxemia were 0.29 (CI 0.15-0.57; p=0.0005) and 0.35 (CI 0.17-0.73; p=0.008) in favor of the CA-group. On average, CA was able to detect imminent mild and severe hypoxemia 83 and 99 seconds before standard monitoring. Standard monitoring represented an independent risk factor for hypoxemia and severe hypoxemia.
CONCLUSIONS: Respiratory complications of sedation during PEG placement are frequent events. CA is able to detect imminent hypoxemia at an early time point. This allows an early intervention and consecutively the avoidance of mild and severe hypoxemia. Therefore, CA monitoring can be recommended particularly during PEG insertion procedures.
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