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Case Reports
Journal Article
Review
Unexpected serious aplastic anemia from PD-1 inhibitors: beyond what we know.
Tumori 2019 December
INTRODUCTION: The recent introduction of checkpoint inhibitor-based immunotherapy has revolutionized the treatment of advanced lung cancers, becoming standard of care in both first- and second-line treatment. New types of toxicity are emerging with the increasingly widespread use of these inhibitors.
CASE PRESENTATION: We describe a case of aplastic anemia in a patient with stage IV non-small cell lung cancer after a single administration of nivolumab.
CONCLUSIONS: Several similar case reports reported in literature show an increasing rate of toxicities from immunotherapy in this setting. These real-world data provide an insight into patient outcomes and treatment decisions being made in clinical practice.
CASE PRESENTATION: We describe a case of aplastic anemia in a patient with stage IV non-small cell lung cancer after a single administration of nivolumab.
CONCLUSIONS: Several similar case reports reported in literature show an increasing rate of toxicities from immunotherapy in this setting. These real-world data provide an insight into patient outcomes and treatment decisions being made in clinical practice.
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