Your institution is subscribed to Read Institutional Edition. Log in or Sign Up to read full text articles.

LETTER

Mast Cell Activation in Dowling-Degos disease

J Knuever, O D Persa, A Illerhaus, D J Ralser, K Hartmann, R C Betz, I Tantcheva-Poór
British Journal of Dermatology 2019 June 17
31206596
Dowling-Degos disease (DDD OMIM 179850) is a rare autosomal-dominant genodermatosis in the spectrum of reticulate pigmented anomalies that usually presents after puberty. It is characterised by reticulate hyperpigmentation and small brownish papules, located at various regions depending on the mutation. Loss-of-function mutations in the genes KRT5, POGLUT1, POFUT1 and PSENEN were identified for DDD. Patients with KRT5 mutations usually develop their lesions at intertriginous areas, whereas patients with POGLUT1 often show affected extremities. Histology reveals downward elongations of rete ridges with a reticulated or fenestrated pattern, occasional horn cysts and basal hyperpigmentation. The phenotype depends on the affected gene. This article is protected by copyright. All rights reserved.

Full Text Links

Find Full Text Links for this Article

Discussion

You are not logged in. Sign Up or Log In to join the discussion.

Related Papers

Remove bar
Read by QxMD icon Read
31206596
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.