Add like
Add dislike
Add to saved papers

Ser625 of msn2 transcription factor is indispensable for ethanol tolerance and alcoholic fermentation process.

The genetic modification of yeast strains can be used as an approach for the improvement of ethanol fermentation. msn2 transcription factor is implicated in yeast stress response and its activation is controlled by Proteine Kinase A (PKA). PKA activation inhibiting the translocation of msn2 to the nucleus. An in silico analysis of msn2 protein sequence revealed serine residue at position 625 as a potent target of PKA. The substitution of this serine residue with alanine has as a result the increase of susceptibility of the cells to ethanol challenge reducing IC50 from 3% v/v to 2.42% v/v. Additionally, cells carrying this substitution, were shown a significantly reduced fermentation rate at 300 C and 180 C increasing the total fermentation time by approximately 2 and 3 times respectively. These results clearly indicate that Ser625 is absolutely necessary for yeast to retain its fermentation ability and ethanol tolerance.

Full text links

We have located links that may give you full text access.
Can't access the paper?
Try logging in through your university/institutional subscription. For a smoother one-click institutional access experience, please use our mobile app.

For the best experience, use the Read mobile app

Mobile app image

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app

All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.

By using this service, you agree to our terms of use and privacy policy.

Your Privacy Choices Toggle icon

You can now claim free CME credits for this literature searchClaim now

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app