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Surgical Site Infections: Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice

Lilian M Abbo, Paolo Antonio Grossi
Clinical Transplantation 2019 May 11, : e13589
These guidelines from the Infectious Diseases Community of Practice of the American Society of Transplantation review the diagnosis, prevention and management of post-operative surgical site infections (SSIs) in solid organ transplantation. SSIs are a significant cause of morbidity and mortality in SOT recipients. Depending on the organ transplanted, SSIs occur in 3 to 53% of patients, with the highest rates observed in small bowel/multivisceral, liver, and pancreas transplant recipients. These infections are classified by increasing invasiveness as superficial incisional, deep incisional, or organ/space SSIs. The spectrum of organisms implicated in SSIs in SOT recipients is more diverse than the general population due to other important factors such as the underlying end stage organ failure, immunosuppression, prolonged hospitalizations, organ transportation/preservation and previous exposures to antibiotics in donors and recipients that could predispose to infections with multidrug-resistant organisms. In this guideline we describe the epidemiology, clinical presentation, differential diagnosis, potential pathogens and management. We also provide recommendations for the selection, dosing, and duration of peri-operative antibiotic prophylaxis to minimize post-operative SSIs. This article is protected by copyright. All rights reserved.


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