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Human umbilical cord blood cells restore vascular integrity in injured rat brain and modulate inflammation in vitro

Amit K Srivastava, Karthik S Prabhakara, Daniel J Kota, Supinder S Bedi, Fabio Triolo, Katherine S Brown, Matthew L Skiles, Heather L Brown, Charles S Cox, Scott D Olson
Regenerative Medicine 2019 May 10
Aim: Traumatic brain injury is a complex condition consisting of a mechanical injury with neurovascular disruption and inflammation with limited clinical interventions available. A growing number of studies report systemic delivery of human umbilical cord blood (HUCB) as a therapy for neural injuries. Materials & methods: HUCB cells from five donors were tested to improve blood-brain barrier integrity in a traumatic brain injury rat model at a dose of 2.5 × 107 cells/kg at 24 or 72 h postinjury and for immunomodulatory activity in vitro . Results & Conclusion: We observed that cells delivered 72 h postinjury significantly restored blood-brain barrier integrity. HUCB cells reduced the amount of TNF-α and IFN-γ released by activated primary rat splenocytes, which correlated with the expression of COX2 and IDO1.


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