Effects of the prophylactic use of taurolidine-citrate lock on the number of catheter related infections in children under two years of age undergoing surgery.

Central venous access poses a risk of developing CRIs. The aim of the study was to evaluate prophylactic use of taurolidine-citrate (T-C) solution on the number of CRIs. 97 catheters, used in 86 children, were randomly divided into 2 groups: T(-) (n=49) - standard aseptic procedures; T(+) (n=48) - additional filling of the catheters with T-C solution during intervals in the cycles of parenteral nutrition or drug supply. A significant difference was found in the number of catheter-related infections in the two groups: T(-) n=16, T(+) n=1 (p<0.05). Use of T-C appears to be a safe and effective method of preventing CRI.