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JOURNAL ARTICLE

Modulation of inflammation in wounds of diabetic patients treated with porcine urinary bladder matrix

John T Paige, Michael Kremer, Jace Landry, Samuel A Hatfield, Donald Wathieu, Aaron Brug, Daniel J Lightell, Kara L Spiller, T Cooper Woods
Regenerative Medicine 2019 April 25
31020913
Aim: To determine if porcine urinary bladder matrix (UBM) treatment is associated with modulation of wound inflammation in diabetic patients. Patients & methods: mRNA associated with M1 and M2 macrophages were measured in wounds of diabetic and nondiabetic patients pre- and post-treatment with UBM and an M1:M2 score was calculated. Results: Wound tissue from diabetic subjects exhibited elevated M1:M2 scores compared with nondiabetic patients, suggesting a greater pro-inflammatory state prior to treatment. Post-treatment, there was significantly greater reduction in the magnitude of the individual M1:M2 scores in the diabetic patients resulting in similar levels in both groups of patients. Conclusions: UBM may assist in diabetic wound healing by restoring an inflammatory state similar to that of nondiabetic patients.

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