MENU ▼
Read by QxMD icon Read
search
OPEN IN READ APP
JOURNAL ARTICLE

Tenofovir alafenamide for hepatitis B virus infection including switching therapy from tenofovir disoproxil fumarate

Shun Kaneko, Masayuki Kurosaki, Nobuharu Tamaki, Jun Itakura, Tsuguru Hayashi, Sakura Kirino, Leona Osawa, Keiya Watakabe, Mao Okada, Wan Wang, Takao Shimizu, Mayu Higuchi, Kenta Takaura, Yutaka Yasui, Kaoru Tsuchiya, Hiroyuki Nakanishi, Yuka Takahashi, Mamoru Watanabe, Namiki Izumi
Journal of Gastroenterology and Hepatology 2019 April 24
31017689

BACKGROUND: Tenofovir alafenamide (TAF) is a new prodrug of tenofovir, enabling treatment of patients with hepatitis B virus (HBV) infection at a lower dose than tenofovir disoproxil fumarate (TDF), via more efficient delivery of tenofovir to the hepatocytes. We compared the efficacy and safety of TDF and TAF and investigated switching from TDF to TAF therapy.

METHODS: Consent for TDF and TAF therapy was obtained from 117 and 67 patients from August 2014 to January 2018. In total, 45 and 14 patients were administered TDF and TAF, respectively, as naïve therapy and 36 patients were switched from TDF to TAF. The antiviral effects and renal function safety were assessed.

RESULTS: At week 48, the antiviral effects on patients receiving TDF and TAF as naïve therapy were similar in terms of reduction of HBV DNA (-5.6±1.8 logIU/ml vs. -5.0±1.7log IU/ml; p=0.34) and hepatitis B surface antigen (HBsAg) (-0.29±0.64 logIU/ml vs. -0.15±0.42 logIU/ml; p=0.71) levels. A significant decrease in the estimated glomerular filtration rate (eGFR) was seen at 48 w TDF treatment (-5.34±7.69 ml/min/1.73m2 ; p<0.001). Switching from TDF to TAF did not increase the HBV DNA or HBsAg at 24 weeks. Although the eGFR worsened during TDF therapy (-7.32±4.87 ml/min/1.73m2 ), it improved significantly at week 4 (+3.93±6.18 ml/min/1.73m2 ; p=0.008) and week 24 (+2.89±4.26 ml/min/1.73m2 ; p=0.020) after switching from TDF to TAF.

CONCLUSION: TDF and TAF showed adequate antiviral effects as naïve therapies. Furthermore, switching from TDF to TAF therapy contributed to the maintenance of the antiviral effect and recovery of renal dysfunction.

Comments

You need to log in or sign up for an account to be able to comment.

No comments yet, be the first to post one!

Related Papers

Available on the App Store

Available on the Play Store
Remove bar
Read by QxMD icon Read
31017689
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"