We have located links that may give you full text access.
Journal Article
Research Support, Non-U.S. Gov't
Aerobic Exercise Improves Food Reward Systems in Obese Rats via Insulin Signaling Regulation of Dopamine Levels in the Nucleus Accumbens.
ACS Chemical Neuroscience 2019 June 20
The dopaminergic pathway, comprising projections from the ventral tegmental area to the nucleus accumbens, constitutes the core of the brain reward system. Insufficient food reward caused by dopamine signaling dysfunction in the nucleus accumbens is an important contributor to obesity and may be associated with insulin signaling. Aerobic exercise has a positive effect on both preventing and treating obesity. In addition, physical exercise is important in striatal dopamine homeostasis and improves insulin sensitivity in the peripheral and central nervous system. Therefore, we hypothesized that aerobic exercise may increase dopamine levels in the nucleus accumbens through insulin signaling, thus improving food reward in obesity. In the present study, we used a rat model of obesity, induced by high fat diet. Obese rats exhibited lower basic dopamine concentration in the nucleus accumbens induced by eating or extracellular insulin, attenuated insulin signaling, and increased fat preference. Interestingly, an 8-week aerobic exercise regimen reversed these symptoms. In addition, we noted a significant increase in insulin Akt/GSK3-β signal transduction in the nucleus accumbens. These data demonstrate that aerobic exercise promotes dopamine levels in the nucleus accumbens through insulin signal transduction, which may constitute an important neurobiological mechanism of exercise against obesity.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app