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Ingenol mebutate for mycosis fungoides.

Ingenol mebutate is a macrocyclic diterpene ester, naturally found in the sap of the Australian plant Euphorbia peplus, which proved efficacious for actinic keratosis. In clinical routine, we observed local improvement of MF upon application of ingenol mebutate in MF patients treated for coincidental actinic keratosis within direct proximity of/overlapping with MF skin lesions. Hence, the objective of this study was to assess the effect of topical ingenol mebutate on MF skin lesions. We offered an individual treatment attempt with ingenol mebutate for one selected MF lesion to three patients with MF stage IA. This article is protected by copyright. All rights reserved.

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