The association between alcohol metabolism and genetic variants of ADH1A, SRPRB, and PGM1 in Korea.

BACKGROUND: Excessive alcohol consumption is a major public health problem in East Asian countries. Alcohol use leads to a cascade of problems including increased chances of risky behavior and wide range of negative health consequences from alcoholic liver disease to upper gastric and liver cancer. These alcohol effects are known to be influenced by ethnic variability and genetics.

METHODS: In this study, subjects were administered a single dose of alcohol (0.6 g/kg for men or 0.4 g/kg for women) and blood alcohol and acetaldehyde concentration were measured 8 times over 5 h. To investigate genetically susceptible factors to alcohol metabolism, we selected single-nucleotide polymorphisms of genes identified by prior genetic association studies for alcohol metabolism, alcohol consumption, alcohol dependence, and related traits, and performed genotyping all subjects (n = 104).

RESULTS: We identified variations in the ADH1A, SRPRB, and PGM1 genes, which are directly associated with blood alcohol or acetaldehyde concentrations. Namely, the T-allele of SRPRB rs17376019 and C-allele of PGM1 rs4643 were associated with lower blood alcohol levels, while the ADH1 rs1229976 C- allele group exhibited markedly higher blood acetaldehyde levels than those of the ADH1 rs1229976 T-allele group.

CONCLUSION: These results suggest that genetic variations in ADH1A, SRPRB, and PGM1 lead to variations in blood alcohol and acetaldehyde concentration after alcohol intake.