JOURNAL ARTICLE

NT-proBNP and Echocardiographic Parameters in Liver Cirrhosis - Correlations with Disease Severity

Alexandru Radu Mihailovici, Ionuț Donoiu, Dan Ionuț Gheonea, Oana Mirea, Georgică Costinel Târtea, Maria Buşe, Veronica Calborean, Cosmin Obleagă, Vlad Pădureanu, Octavian Istrătoaie
Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre 2019 April 16
30995644
determined. Liver disease severity in patients with cirrhosis was established by Child-Pugh class, MELD score and presence/absence of ascites. Results: Plasma levels of NT-proBNP were significantly higher in cirrhotic patients than in the healthy subjects. NT-proBNP levels were also significantly elevated in Child-Pugh class C patients compared to those in class B and A. Left atrium size, diastolic function, left ventricular wall thickness and left ventricular ejection fraction were significantly altered in cirrhotic patients compared to controls. Advanced cirrhosis and high levels of NT-proBNP were significantly associated with increased left atrium volume and signs of cardiac diastolic dysfunction. We also observed significant differences between quartile groups of MELD score for the following: NT-proBNP, Troponin I, left atrium volume, left ventricle wall thickness, lateral wall and septum systolic tissue doppler velocities and global longitudinal strain. Conclusion: NT-proBNP is increased in patients with cirrhosis and is correlated with the severity of liver disease as established by Child-Pugh class, MELD score and presence of ascites.

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