Read by QxMD icon Read

Impact of 2016 WHO diagnosis of early and overt primary myelofibrosis on presentation and outcome of 232 patients treated with ruxolitinib

Francesca Palandri, Giuseppe A Palumbo, Elisabetta Abruzzese, Alessandra Iurlo, Nicola Polverelli, Elena Elli, Massimiliano Bonifacio, Micaela Bergamaschi, Bruno Martino, Mario Tiribelli, Giulia Benevolo, Alessia Tieghi, Nicola Sgherza, Alessandro Isidori, Gianni Binotto, Monica Crugnola, Florian Heidel, Francesco Cavazzini, Costanza Bosi, Giuseppe Auteri, Daniele Cattaneo, Robin Foà, Roberto M Lemoli, Antonio Cuneo, Mauro Krampera, Daniela Bartoletti, Michele Cavo, Nicola Vianelli, Massimo Breccia, Roberto Latagliata
Hematological Oncology 2019 April 15
The 2016 WHO criteria identified early primary myelofibrosis (PMF) as an individual entity with milder clinical features and better outcome compared with overt PMF. Here, we compared early and overt PMF patients treated with ruxolitinib in terms of baseline clinical/laboratory characteristics, response, and toxicity to treatment. We observed that early-PMF patients achieve better and more stable spleen and symptoms responses, with significantly lower rates of hematological toxicities. No differences in overall and leukemia-free survival were detected between the two cohorts. The application of 2016 WHO criteria is crucial to identify those PMF patients who deserve a stricter monitoring during treatment.


You need to log in or sign up for an account to be able to comment.

No comments yet, be the first to post one!

Related Papers

Available on the App Store

Available on the Play Store
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"