Cerebrolysin attenuates ethanol-induced spatial memory impairments through inhibition of hippocampal oxidative stress and apoptotic cell death in rats

Ladan Vaghef, Fereshteh Farajdokht, Marjan Erfani, Alireza Majdi, Saeed Sadigh-Eteghad, Pouran Karimi, Siamak Sandoghchian Shotorbani, Manouchehr Seyedi Vafaee, Javad Mahmoudi
Alcohol 2019 April 11
The present study investigates the potential neuroprotective effect of cerebrolysin (CBL), a combination of neurotrophic factors, on the cognitive and biochemical alterations induced by chronic ethanol administration in rats. The animals were divided into 5 groups as follows: Control, ethanol (4 g/kg, for 30 days) plus normal saline (Ethanol + NS), ethanol plus CBL 1 ml/kg (Ethanol + CBL 1), ethanol plus CBL 2.5 ml/kg (Ethanol + CBL 2.5), and ethanol plus CBL 5 ml/kg (Ethanol + CBL 5). Morris water maze (MWM) test was performed to assess cognitive impairment. The status of the lipid peroxidation marker (MDA), antioxidant capacity as well as alterations of the apoptotic factors such as Bcl-2, BAX, and cleaved-caspase 9 and 3 were evaluated in the hippocampus. The results showed that CBL treatment not only normalized the increased MDA levels in the alcoholic rats and enhanced antioxidant defense but also reduced Bax/Bcl-2 ratio and cleaved-caspase 9 and 3 in the hippocampus. These results were parallel with improvement in the spatial memory performance in the MWM test. The findings of the present study provide evidence for the promising therapeutic effect of CBL in chronic ethanol consumption through counteracting oxidative stress and apoptosis markers.

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