Allergy to Mus m 1: Allergy to Mus m 1: a review of structural, and immunological features

Marlon Múnera, Andres Sanchez, Jorge Sánchez, Maria Nordmann, Mariana Perez, Dilia Aparicio
Immunology Letters 2019 April 9
The prevalence of allergies to pets has been increasing over the past decades. Some of the most important animal-derived allergens are members of the lipocalin protein family, which are found in dander, saliva, and urine. These allergens disperse effectively and are widely present in indoor environments. Exposure to high levels of mouse urinary protein (Mus m 1, hereinafter called 'mouse allergen') has been previously linked to sensitization to mouse, and indicators of asthma severity or control in some studies. To date, this is the only known mouse allergen registered in the IUIS database. This allergen is responsible for 27% of the total T cell response, confirming the dominant role it plays in mouse allergy. Mice have a worldwide distribution affecting both rural and urban areas; hence humans are frequently exposed to mouse-derived proteins. Additionally, exposure to mouse allergens has increased since they are more frequently being made pets, and in addition, exposure of laboratory animal care personnel to mice has been associated with a high risk of developing occupational allergies. Mus m 1 has been recognized as the main mouse allergen, and several studies suggest its clinical relevance. What makes Mus m 1 such an important allergen? In this review, we explored its structural, immunological, and clinical features.

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