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DNA origami as scaffolds for self-assembly of lipids and proteins.

Since first reported in 2006, the DNA origami approach has attracted increasingly more attention due to their programmable shapes, structural stability, bio-compatibility and fantastic addressability. Here in this review, we will focus on the recent development of DNA origami as scaffolds for templating self-assembly of distinct bio-components, basically proteins and lipids, into a diverse spectrum of integrative supramolecular architectures. First, the historical development of DNA origami concept will be briefly reviewed. Next, we will discuss various applications of DNA origami constructs in controllable directed assembly of soluble proteins. Manipulation and self-assembly of lipid membranes and membrane proteins by using DNA origami as a scaffold will be addressed. Recent progress in applying DNA origami in cryoelectron microscopy analysis will also be discussed. These advances collectively emphasize that the DNA origami approach is a highly versatile, fast evolving tool that may be integrated with lipids and proteins in a way that meets the future challenge in molecular biology and nanomedicine.

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