Androgens and depression: a review and update.

PURPOSE OF REVIEW: The aim of this study is to summarize recently published literature examining androgens and depression.

RECENT FINDINGS: The impact of androgen levels, androgen replacement therapy and pharmacologic androgen deprivation on depression and depressive symptoms remain active areas of investigation. Recent publications support the finding that testosterone replacement therapy in men with low testosterone may improve depression, and that androgen deprivation therapy in men with prostate cancer may contribute to depression.

SUMMARY: We review the recent literature on androgens and depression and highlight key developments.