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Deciphering mechanisms of response and resistance in large-scale mouse cancer screens

Anirudh Prahallad, Michael Rugaard Jensen, Emilie Anne Chapeau
Current Opinion in Genetics & Development 2019 April 3, 54: 48-54
Acquired resistance is a major limitation for the successful treatment of cancer patients. Although numerous efficacious cancer therapeutics have been developed in the past decades, resistance arises due to a variety of reasons including tumoral genetic alterations, or modulation of factors in the tumor environment. Understanding the mechanistic reasons for tumor relapse supports the identification of novel combination therapies that could lead to more durable responses. Here, we will review large-scale in vivo screens in pre-clinical cancer models that employed genetic and pharmacological agents toward elucidating acquired drug resistance and informing on beneficial combinations to be tested in clinical trials.


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