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Do we need to remove rapidly central venous catheter to treat Staphylococcus aureus related-catheter bloodstream infection (CR-BSI) in neonates and children? A 8-year period (2010-2017) retrospective analysis in a French University Hospital

Boussamet L, Launay E, Thomas E, Gras Leguen C, Lepelletier D
Journal of Hospital Infection 2019 April 4
Catheter-relate bloodstream infection (CR-BSI) treatment is based on empiric antibiotherapy associated with or without catheter removal. The aim of this study was to compare the incidence of failures in neonates and children with S. aureus CR-BSI with or without rapid catheter removal. Treatment failure was defined as the persistence of positive blood cultures, onset or aggravation of a local or systemic complication or relapse. We analyzed 54 CR-BSI in 225 patients (33 and 21 conservative and non-conservative treatments) with 3 and 10 failures, respectively (P<0.002). Non-conservative treatment with rapid catheter removal seems to be associated with significant lower failure rate and should be recommended.


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