We have located links that may give you full text access.
Ligand Exchange Thin Layer Chromatographic Enantioresolution of (RS)-Ketorolac and (RS)-Etodolac and Recovery of Native Enantiomers.
Journal of Chromatographic Science 2019 April 4
Direct resolution of (RS)-ketorolac and (RS)-etodolac has been achieved by ligand exchange thin layer chromatography. Cu(II) has been used as a complexing ion with three enantiomerically pure amino acids (namely, l-tryptophan, l-histidine and l-phenylalanine) as chiral dopants. Chromatograms were developed using different combinations of solvent systems in different ratio having no chiral additive. Iodine vapors were used for location of spots. Different experimental factors, i.e., effect of temperature, mole ratio of Cu(II) to l-amino acids and solvent ratio were optimized in order to improve the separation efficiency. Results have been compared (for RF and Rs). Limit of detection for each enantiomer of both the racemic analytes (ketorolac and etodolac) was found to be 0.6 and 0.8μg.
Full text links
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app