Genetic association of retroesophageal left brachiocephalic vein.

Retroesophageal (RE) left brachiocephalic vein (LBCV) is rare. It takes an anomalous route to run posteriorly behind the trachea and esophagus before draining into the superior vena cava via the azygos vein (Figure 1). Isolated RELBCV causes no symptoms. Seven postnatal and six prenatal cases have been reported1,2,3,4,5 , and here we add four more prenatal cases to the list (Table 1). Among the 17 reported cases of RELBCV, five had genetic anomalies, including three RASopathies (Case 2,4,8), one 22q11.2 microdeletion syndrome (Case 1) and one complex chromosomal abnormality (Case 9). This article is protected by copyright. All rights reserved.