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Silver triethanolamine-loaded PVB/CO films for a potential liquid bandage application

Fengzhen Zhou, Wenjing Wang, Huiling Guo
Journal of Biomaterials Applications 2019 April 1, : 885328219835361
Many studies have reported that silver has excellent antibacterial properties. However, silver ions can easily react with oxygen to form Ag2 O, thus leading to a color change and a reduction in its anti-microbial characteristics. In this study, silver triethanolamine- (ST) loaded PVB/CO solution was prepared as a potential candidate liquid bandage. PVB/CO/ST retained high transparency after exposure to light for 12 months, which allowed convenient inspection of the wound bed without removal of the dressing. The PVB/CO/ST film exhibited favorable properties, such as speed of drying, excellent tensile strength and elongation characteristics and water vapor transmission rate (WVTR). It was comfortable and waterproof, and therefore effective at preventing bacterial invasion, providing effective biosafety. PVB/CO/ST solution-treated wounds exhibited accelerated healing and reduced inflammation in a nude mouse mode. Our data suggested that PVB/CO/ST solution could serve as a promising liquid bandage for treatment of minor trauma.


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