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Treatment of Multiple Myeloma: ASCO and CCO Joint Clinical Practice Guideline

Joseph Mikhael, Nofisat Ismaila, Matthew C Cheung, Caitlin Costello, Madhav V Dhodapkar, Shaji Kumar, Martha Lacy, Brea Lipe, Richard F Little, Anna Nikonova, James Omel, Namrata Peswani, Anca Prica, Noopur Raje, Rahul Seth, David H Vesole, Irwin Walker, Alexander Whitley, Tanya M Wildes, Sandy W Wong, Tom Martin
Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology 2019 April 1, : JCO1802096

PURPOSE: To provide evidence-based recommendations on the treatment of multiple myeloma to practicing physicians and others.

METHODS: ASCO and Cancer Care Ontario convened an Expert Panel of medical oncology, surgery, radiation oncology, and advocacy experts to conduct a literature search, which included systematic reviews, meta-analyses, randomized controlled trials, and some phase II studies published from 2005 through 2018. Outcomes of interest included survival, progression-free survival, response rate, and quality of life. Expert Panel members used available evidence and informal consensus to develop evidence-based guideline recommendations.

RESULTS: The literature search identified 124 relevant studies to inform the evidence base for this guideline.

RECOMMENDATIONS: Evidence-based recommendations were developed for patients with multiple myeloma who are transplantation eligible and those who are ineligible and for patients with relapsed or refractory disease.


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