A new sub-stage classification strategy for Barcelona Clinic Liver Cancer stage B patients with hepatocellular carcinoma

Ke-Shu Hu, Bei Tang, Jia Yuan, Shen-Xin Lu, Miao Li, Rong-Xin Chen, Lan Zhang, Zheng-Gang Ren, Xin Yin
Journal of Gastroenterology and Hepatology 2019 April 1

BACKGROUND AND AIM: Patients with Barcelona Clinic Liver Cancer stage B hepatocellular carcinoma are heterogeneous population, and the classifications available could not predict the prognosis accurately. Herein, we proposed a new sub-stage classification method, Scoring Method for Intermediate Stage, for precise classification and clinical guidance in hepatocellular carcinoma patients within Barcelona Clinic Liver Cancer stage B.

METHODS: 1026 stage B patients of hepatocellular carcinoma who underwent transcatheter arterial chemoembolization as first line treatment in liver cancer institute, Zhongshan hospital, Fudan University were retrospectively enrolled. The prognostic evaluation ability of the new sub-stage classification criteria were analyzed, in comparison with the existing sub-stage classification criteria.

RESULTS: Using Scoring Method for Intermediate Stage, 1026 stage B patients were subclassified into three subgroups, based on Child-Pugh score and Up-to-7 grade, as B1 (scoring 2), B2 (scoring 3 or 4) and B3 (scoring 5 or 6). The median survival time of the three sub stages was 29 (95%CI: 25-36), 19 (95%CI: 16-21) and 10 (95%CI: 8-12) months respectively. More favorable discrimination efficacy was identified by the new criteria in comparison with the existing sub-stage classification criteria, including Bolondi, Kinki, MICAN and Kim criteria. Moreover, multivariate analyses indicated that the novel classification was highly associated with prognosis (HR=1.63, 95% CI: 1.43-1.86, P<0.001).

CONCLUSIONS: Scoring Method for Intermediate Stage demonstrates satisfying capacity in classifying patients with stage B hepatocellular carcinoma and predicting prognosis.


You are not logged in. Sign Up or Log In to join the discussion.

Related Papers

Available on the App Store

Available on the Play Store
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"