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Effect of C-2 substitution on the stability of non-traditional cephalosporins in mouse plasma.

Matthew Zimmerman, Stacey L McDonald, Hsin-Pin Ho-Liang, Patrick Porubsky, Quyen Nguyen, Cameron W Pharr, Andrew J Perkowski, Robert Smith, Frank J Schoenen, Ben S Gold, David Zhang, Carl F Nathan, Véronique Dartois, Jeffrey Aubé
Journal of Antibiotics 2019 March 23
A systematic study of the stability of a set of cephalosporins in mouse plasma reveals that cephalosporins lacking an acidic moiety at C-2 may be vulnerable to β-lactam cleavage in mouse plasma.

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