Mysterious effects of olfactory pathway lesions on intestinal immunodeficiency targeting Peyer's patches: The first experimental study

Binali Firinci, Ozgur Caglar, Erdem Karadeniz, Ali Ahiskalioglu, Tuba Demirci, Mehmet Dumlu Aydin
Medical Hypotheses 2019, 125: 31-36

BACKGROUND: Although olfaction has been considered as important neuroimmunomodulatory foundation, there is no satisfying analytical information between neurohistomorphological features olfactory networks and intestinal immune system hardwares. We studied if the olfactory bulb lesions (OBL) may rely on histopathological features of intestinal lymphatic Peyer's patches in an animal model.

METHODS: Thirty-two rats were grouped as control (Group I, n = 8), SHAM (Group II, n = 7) and OBL (Group III, n = 17) respectively; and followed eight weeks and animals were decapitated. The olfactory bulbs and intestines were extracted. Specimens stained with hematoxylin/eosin and GFAP methods and analyzed Stereologically to evaluate volume loss of olfactory bulbs and Peyer's patches volumes (PV) of intestines per cubic millimeter and compared with each other's statistically.

RESULTS: The mean olfactory bulbs volumes were estimated as 3.65 ± 0.32/mm3 in group I, 3.12 ± 0.20/mm3 in group II and 2.21 ± 0.15/mm3 in group III (p < 0.0005 Group III vs. I and II). The mean of PV were estimated as; (9 ± 2) × 106  µm3 /cm3 in Group-I, (12 ± 3) × 106  µm3 /cm3 in Group-II; and (23 ± 4) × 106  µm3 /cm3 in group-III (p < 0.005 Group II vs. I, p < 0.0005 Group III vs. I-II).

CONCLUSIONS: OBL could rely on intestinal immunodeficiency causing by olfaction loss induced denervation injury of Peyer's patches.

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