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Molecularly imprinted polymeric shell coated monodisperse-porous silica microspheres as a stationary phase for microfluidic boronate affinity chromatography.

Molecular imprinting of cis-diol functionalized agents via boronate affinity interaction has been usually performed using nanoparticles as supports which can not be utilized as a stationary phase in continuous microcolumn applications. In this study, monodisperse-porous, spherical silica particles in micron-size range, with bimodal pore diameter distribution were selected as a new support for the synthesis of a molecularly imprinted boronate affinity sorbent, using a cis-diol functionalized agent as the template. A specific surface area of 158 m2 /g was achieved with the imprinted sorbent by using monodisperse-porous silica microspheres containing both mesoporous and macroporous compartments as the support. High porosity originating from macroporous compartment and sufficiently high particle size provided good column-permeability to the imprinted sorbent in microcolumn applications. The mesoporous compartment provided a large surface area for parking of imprinted molecule while the macroporous compartment facilitated the intraparticular diffusion of imprinted target within the microsphere interior. A microfluidic boronate affinity system was first constructed by using molecularly imprinted polymeric shell coated monodisperse-porous silica microspheres as a stationary phase. The synthetic route for imprinting process, the reversible adsorption/ desorption behavior of selected target and the selectivity of imprinted sorbent in both batch and microfluidic boronate affinity chromatography systems are reported. This article is protected by copyright. All rights reserved.

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