OTOR in breast carcinoma as a potent prognostic predictor correlates with cell proliferation, migration and invasion.

Otoraplin (OTOR), recognized as an important cochlear gene, has a predicted secretion signal peptide sequence and harbors a high degree of cross-species conservation. However, its role in tumor progression is relatively unclear, especially in breast carcinoma (BC). This study aimed to investigate clinicopathologic significance of OTOR in breast infiltrating ductal carcinoma (IDC) with high metastasis and unveil its biological function in BC. OTOR was highly overexpressed in BC tissues and cells compared with normal samples. OTOR overexpression was associated with a few of clinicopathologic characteristics and worse overall survival (OS) of IDC breast patients. Silencing of OTOR using siRNA tool impeded BC cells proliferation, migration and invasion by CCK-8, colony formation, wound-healing and transwell assays, which might be regulated by mitogen-activated protein kinase/extracellular signal regulated kinase -extracellular signal-regulated kinase (MEK-ERK) signaling inactivation. These results indicate that OTOR plays a crucial role in BC prognosis and progression, which could potentially aid to determining therapeutic target assisting future patient treatment for BC.